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M9480480.TXT
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1994-08-20
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Document 0480
DOCN M9480480
TI Rochalimaea antibodies in HIV-associated neurologic disease.
DT 9410
AU Schwartzman WA; Patnaik M; Barka NE; Peter JB; Section of Infectious
Diseases, UCLA Department of Medicine.
SO Neurology. 1994 Jul;44(7):1312-6. Unique Identifier : AIDSLINE
MED/94309818
AB Rochalimaea henselae, a recently described pathogen thought to cause
syndromes as varied as bacillary angiomatosis, parenchymal bacillary
peliosis, fever with bacteremia, and cat-scratch disease, is associated
with CNS diseases including cerebral and retinal bacillary angiomatosis,
as well as cat-scratch-related encephalitis, myelitis, cerebral
arteritis, and retinitis. We used a newly developed enzyme immunoassay
and the polymerase chain reaction to investigate the association of R
henselae infection with HIV-related CNS disease and found that whereas
seroprevalence rates in HIV-positive patients unselected for neurologic
disease were 4% to 5.5%, those with neurologic disease had
seroprevalence rates of 32%. The ratio of organism-specific antibodies
in CSF compared with serum suggested intra-blood-brain-barrier synthesis
of these antibodies. CSF specimens containing only R henselae IgM had
16S rDNA specific for R henselae. Stored serum from one of these
patients indicated he had developed R henselae-reactive IgM antibodies
10 months prior to the onset of neurologic disease. In the 14 patients
for whom clinical data were available, evidence of CNS invasion by R
henselae was accompanied by acute and subacute mental status changes
including hallucinations, disorientation, and rapidly progressive
dementia.
DE Adult Antibodies/*ANALYSIS AIDS-Associated
Nephropathy/IMMUNOLOGY/*MICROBIOLOGY Base Sequence Case Report
Comparative Study Human HIV Seropositivity/IMMUNOLOGY/MICROBIOLOGY
Immunoenzyme Techniques Male Molecular Probes/GENETICS Molecular
Sequence Data Polymerase Chain Reaction Rickettsiaceae/*IMMUNOLOGY
Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).